PI=placebo; Rx=treatment
Shepherd J et al. N Engl J Med. 1995;333:1301-1307.
4S Study Group. Lancet. 1995;345:1274-1275.
Sacks FM et al. N Engl J Med. 1996;335:1001-1009.
Downs JR et al. JAMA. 1998;279:1615-1622.
Tonkin A. Presented at AHA Scientific Sessions, 1997.
Mean LDL-C level at follow-up (mg/dL)
Relation Between CHD Events and LDL-C in Recent Statin Trials
0
5
10
15
20
25
30
90
110
130
150
170
190
210
% with
CHD event
CARE-Rx
LIPID-Rx
4S-Rx
CARE-PI
LIPID-PI
4S-PI
2° Prevention
1° Prevention
WOSCOPS-PI
WOSCOPS-Rx
AFCAPS/TexCAPS-Rx
AFCAPS/TexCAPS-PI
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