PPT Slide

Why Diabetics Require Aggressive Risk Factor Modification

Vasculopathy: lipid deposition, monocyte proliferation,

smooth muscle proliferation, mural fibrosis

Schneider & Sobel, Clin Cardiol 1997

• More severe and diffuse CAD

• Disturbed lipid metabolism

• Deranged autonomic function

• Altered carbohydrate and lipid metabolism

• Reduced HDL and increased VLDL and LDL

• Diabetics with CHD do worse than non-diabetics

  • Worse mortality
  • Worse results after PCI
  • Unreliable symptoms

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